Can the 2-(13)C-uracil breath test be used to predict the effect of the antitumor drug S-1? by Ishii Yukimoto, Suzuki Shigeru, Takahashi Yasuo, Takayama Tadatoshi, Asai Satoshi in Cancer chemotherapy and pharmacology (2010). PubMed

Abstract

S-1 is an oral anticancer drug containing tegafur (FT), a pro-drug of fluorouracil, combined with two modulators, 5-chloro-2,4-dihydroxypyridine and potassium oxonate (Oxo), at a molar ratio of 1:0.4:1. CYP2A6 genetic polymorphism and dihydropyrimidine dehydrogenase (DPD) inhibition are important for the antitumor effect of S-1. Exploiting the usefulness of the 2-(13)C-uracil breath test (UrBT) as an indicator of DPD activity, we examined whether the results of CYP2A6 genetic polymorphism analysis and UrBT could be used to predict the antitumor effect of S-1.

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