Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1 by Ha Choi Ji, Wah Yee Sook, Kim Mee J, Nguyen Loan, Ho Lee Jeong, Kang Ji-One, Hesselson Stephanie, Castro Richard A, Stryke Doug, Johns Susan J, Kwok Pui-Yan, Ferrin Thomas E, Goo Lee Min, Black Brain L, Ahituv Nadav, Giacomini Kathleen M in Pharmacogenetics and genomics (2009). PubMed

Abstract

Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs. In this study, we characterized the transcriptional effects of five polymorphic variants and six common haplotypes in the basal promoter region of MATE1 that were identified in 272 DNA samples from ethnically diverse US populations.

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