Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease by Hara Kenju, Shiga Atsushi, Fukutake Toshio, Nozaki Hiroaki, Miyashita Akinori, Yokoseki Akio, Kawata Hirotoshi, Koyama Akihide, Arima Kunimasa, Takahashi Toshiaki, Ikeda Mari, Shiota Hiroshi, Tamura Masato, Shimoe Yutaka, Hirayama Mikio, Arisato Takayo, Yanagawa Sohei, Tanaka Akira, Nakano Imaharu, Ikeda Shu-ichi, Yoshida Yutaka, Yamamoto Tadashi, Ikeuchi Takeshi, Kuwano Ryozo, Nishizawa Masatoyo, Tsuji Shoji, Onodera Osamu in The New England journal of medicine (2009). PubMed

Abstract

The genetic cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic, nonhypertensive, cerebral small-vessel disease with associated alopecia and spondylosis, is unclear.

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