DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer by Kalikaki Aristea, Kanaki Maria, Vassalou Helen, Souglakos John, Voutsina Alexandra, Georgoulias Vassilis, Mavroudis Dimitris in Clinical lung cancer (2009). PubMed

Abstract

Genetic polymorphisms of genes involved in DNA repair and glutathione metabolic pathways may affect patients' response to platinum-based chemotherapy. We retrospectively assessed whether single nucleotide polymorphisms (SNP) of DNA-repair genes ERCC1, XPD, XRCC1 and glutathione S-transferase genes GSTP1, GSTT1 and GSTM1 predict overall survival (OS), response and toxicity in 119 non-small-cell lung cancer (NSCLC) patients treated with platinum-based regimens as first- or second-line chemotherapy.

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