Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia by Mullighan Charles G, Su Xiaoping, Zhang Jinghui, Radtke Ina, Phillips Letha A A, Miller Christopher B, Ma Jing, Liu Wei, Cheng Cheng, Schulman Brenda A, Harvey Richard C, Chen I-Ming, Clifford Robert J, Carroll William L, Reaman Gregory, Bowman W Paul, Devidas Meenakshi, Gerhard Daniela S, Yang Wenjian, Relling Mary V, Shurtleff Sheila A, Campana Dario, Borowitz Michael J, Pui Ching-Hon, Smith Malcolm, Hunger Stephen P, Willman Cheryl L, Downing James R, Children's Oncology Group in The New England journal of medicine (2009). PubMed

Abstract

Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined.

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