VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans by Limdi Nita A, Beasley T Mark, Crowley Michael R, Goldstein Joyce A, Rieder Mark J, Flockhart David A, Arnett Donna K, Acton Ronald T, Liu Nianjun in Pharmacogenomics (2008). PubMed

Abstract

Although the influence of VKORC1 and CYP2C9 polymorphisms on warfarin response has been studied, variability in dose explained by CYP2C9 and VKORC1 is lower among African-Americans compared with European-Americans. This has lead investigators to hypothesize that assessment of VKORC1 haplotypes may help capture a greater proportion of the variability in dose for this under-represented group. However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort.

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