G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics by Kohlrausch Fabiana B, Salatino-Oliveira Angélica, Gama Clarissa S, Lobato Maria Inês, Belmonte-de-Abreu Paulo, Hutz Mara H in Pharmacogenomics (2008). PubMed

Abstract

Clozapine treatment of schizophrenia is effective only in 30-60% of individuals. Since genetic factors are believed to play a significant role in the variation of response to antipsychotics, the aim of the present study was to verify the effect of a G-protein gene polymorphism on clozapine response and clozapine-induced generalized seizures in Brazilian patients with schizophrenia.

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