Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression by Kwan Patrick, Poon Wai Sang, Ng Ho-Keung, Kang David E, Wong Virginia, Ng Ping Wing, Lui Colin H T, Sin Ngai Chuen, Wong Ka S, Baum Larry in Pharmacogenetics and genomics (2008). PubMed

Abstract

Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment is ineffective in 30% of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes. We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels.

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