Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24) by Ujiie Shuta, Sasaki Takamitsu, Mizugaki Michinao, Ishikawa Masaaki, Hiratsuka Masahiro in Pharmacogenetics and genomics (2008). PubMed

Abstract

Thiopurine S-methyltransferase (TPMT) is an enzyme responsible for the detoxification of the widely used thiopurine drugs. TPMT is genetically polymorphic and is associated with large interindividual variations in thiopurine drug toxicity and therapeutic efficacy. In this study, we performed an in-vitro analysis of TPMT variant alleles, namely, TPMT*2, *3A, *3B, *3C, *5, *6, *7, *8, *9, *10, *11, *12, *13, *14, *16, *17, *18, *19, *20, *21, *22, *23, and *24.

[ hide abstract ]

Discussed In Paper

Variant Annotations

Sign in to see variant annotations.