Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients by Wyen Christoph, Hendra Heidy, Vogel Martin, Hoffmann Christian, Knechten Heribert, Brockmeyer Norbert H, Bogner Johannes R, Rockstroh Jürgen, Esser Stefan, Jaeger Hans, Harrer Thomas, Mauss Stefan, van Lunzen Jan, Skoetz Nicole, Jetter Alexander, Groneuer Christiane, Fätkenheuer Gerd, Khoo Saye H, Egan Deirdre, Back David J, Owen Andrew, German Competence Network for HIV/AIDS in The Journal of antimicrobial chemotherapy (2008). PubMed

Abstract

The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations of efavirenz and nevirapine.

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