Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer by Gudmundsson Julius, Sulem Patrick, Rafnar Thorunn, Bergthorsson Jon T, Manolescu Andrei, Gudbjartsson Daniel, Agnarsson Bjarni A, Sigurdsson Asgeir, Benediktsdottir Kristrun R, Blondal Thorarinn, Jakobsdottir Margret, Stacey Simon N, Kostic Jelena, Kristinsson Kari T, Birgisdottir Birgitta, Ghosh Shyamali, Magnusdottir Droplaug N, Thorlacius Steinunn, Thorleifsson Gudmar, Zheng S Lilly, Sun Jielin, Chang Bao-Li, Elmore J Bradford, Breyer Joan P, McReynolds Kate M, Bradley Kevin M, Yaspan Brian L, Wiklund Fredrik, Stattin Par, Lindström Sara, Adami Hans-Olov, McDonnell Shannon K, Schaid Daniel J, Cunningham Julie M, Wang Liang, Cerhan James R, St Sauver Jennifer L, Isaacs Sara D, Wiley Kathleen E, Partin Alan W, Walsh Patrick C, Polo Sonia, Ruiz-Echarri Manuel, Navarrete Sebastian, Fuertes Fernando, Saez Berta, Godino Javier, Weijerman Philip C, Swinkels Dorine W, Aben Katja K, Witjes J Alfred, Suarez Brian K, Helfand Brian T, Frigge Michael L, Kristjansson Kristleifur, Ober Carole, Jonsson Eirikur, Einarsson Gudmundur V, Xu Jianfeng, Gronberg Henrik, Smith Jeffrey R, Thibodeau Stephen N, Isaacs William B, Catalona William J, Mayordomo Jose I, Kiemeney Lambertus A, Barkardottir Rosa B, Gulcher Jeffrey R, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari in Nature genetics (2008). PubMed

Abstract

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

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