Cystatin C modulates cerebral beta-amyloidosis by Kaeser Stephan A, Herzig Martin C, Coomaraswamy Janaky, Kilger Ellen, Selenica Maj-Linda, Winkler David T, Staufenbiel Matthias, Levy Efrat, Grubb Anders, Jucker Mathias in Nature genetics (2007). PubMed

Abstract

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

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