Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models by Mi Weiqian, Pawlik Monika, Sastre Magdalena, Jung Sonia S, Radvinsky David S, Klein Andrew M, Sommer John, Schmidt Stephen D, Nixon Ralph A, Mathews Paul M, Levy Efrat in Nature genetics (2007). PubMed

Abstract

Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease.

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