Complement C3 variant and the risk of age-related macular degeneration by Yates John R W, Sepp Tiina, Matharu Baljinder K, Khan Jane C, Thurlby Deborah A, Shahid Humma, Clayton David G, Hayward Caroline, Morgan Joanne, Wright Alan F, Armbrecht Ana Maria, Dhillon Baljean, Deary Ian J, Redmond Elizabeth, Bird Alan C, Moore Anthony T, Genetic Factors in AMD Study Group in The New England journal of medicine (2007). PubMed

Abstract

Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis.

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