Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes by Gudmundsson Julius, Sulem Patrick, Steinthorsdottir Valgerdur, Bergthorsson Jon T, Thorleifsson Gudmar, Manolescu Andrei, Rafnar Thorunn, Gudbjartsson Daniel, Agnarsson Bjarni A, Baker Adam, Sigurdsson Asgeir, Benediktsdottir Kristrun R, Jakobsdottir Margret, Blondal Thorarinn, Stacey Simon N, Helgason Agnar, Gunnarsdottir Steinunn, Olafsdottir Adalheidur, Kristinsson Kari T, Birgisdottir Birgitta, Ghosh Shyamali, Thorlacius Steinunn, Magnusdottir Dana, Stefansdottir Gerdur, Kristjansson Kristleifur, Bagger Yu, Wilensky Robert L, Reilly Muredach P, Morris Andrew D, Kimber Charlotte H, Adeyemo Adebowale, Chen Yuanxiu, Zhou Jie, So Wing-Yee, Tong Peter C Y, Ng Maggie C Y, Hansen Torben, Andersen Gitte, Borch-Johnsen Knut, Jorgensen Torben, Tres Alejandro, Fuertes Fernando, Ruiz-Echarri Manuel, Asin Laura, Saez Berta, van Boven Erica, Klaver Siem, Swinkels Dorine W, Aben Katja K, Graif Theresa, Cashy John, Suarez Brian K, van Vierssen Trip Onco, Frigge Michael L, Ober Carole, Hofker Marten H, Wijmenga Cisca, Christiansen Claus, Rader Daniel J, Palmer Colin N A, Rotimi Charles, Chan Juliana C N, Pedersen Oluf, Sigurdsson Gunnar, Benediktsson Rafn, Jonsson Eirikur, Einarsson Gudmundur V, Mayordomo Jose I, Catalona William J, Kiemeney Lambertus A, Barkardottir Rosa B, Gulcher Jeffrey R, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari in Nature genetics (2007). PubMed

Abstract

We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.

[ hide abstract ]

Discussed In Paper