Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study by Kohsaka Shun, Volcik Kelly A, Folsom Aaron R, Wu Kenneth K, Ballantyne Christie M, Willerson James T, Boerwinkle Eric in Atherosclerosis (2008). PubMed

Abstract

A hallmark feature of atherosclerosis is inflammation mediated by prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study explored whether the COX-2 G-765C polymorphism contributes to increased incidence of coronary heart disease (CHD) or stroke in the large prospective Atherosclerosis Risk in Communities (ARIC) Study.

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