Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1) by Lee Craig R, Bottone Frank G, Krahn Joseph M, Li Leping, Mohrenweiser Harvey W, Cook Molly E, Petrovich Robert M, Bell Douglas A, Eling Thomas E, Zeldin Darryl C in Pharmacogenetics and genomics (2007). PubMed

Abstract

Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1.

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