Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors by Oldenburg Jan, Kraggerud Sigrid M, Cvancarova Milada, Lothe Ragnhild A, Fossa Sophie D in Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2007). PubMed

Abstract

Cisplatin, a cornerstone of combination chemotherapy in the treatment of testicular cancer, induces hearing impairment with considerable interindividual variations. These differences might be a result of functional polymorphisms in cisplatin-detoxifying enzymes like glutathione S-transferases (GSTs).

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