ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment by Crettol Séverine, Déglon Jean-Jacques, Besson Jacques, Croquette-Krokar Marina, Hämmig Robert, Gothuey Isabelle, Monnat Martine, Eap Chin B in Clinical pharmacology and therapeutics (2006). PubMed

Abstract

The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment.

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