Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance by Hukkanen Janne, Jacob Peyton, Benowitz Neal L in Clinical pharmacology and therapeutics (2006). PubMed

Abstract

Grapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit juice on the pharmacokinetics of nicotine, which is primarily metabolized by the CYP2A6 enzyme.

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