Sequence variations in PCSK9, low LDL, and protection against coronary heart disease by Cohen Jonathan C, Boerwinkle Eric, Mosley Thomas H, Hobbs Helen H in The New England journal of medicine (2006). PubMed

Abstract

A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population.

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