Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients by Rotger Margalida, Colombo Sara, Furrer Hansjakob, Bleiber Gabriela, Buclin Thierry, Lee Belle L, Keiser Olivia, Biollaz Jérôme, Décosterd Laurent, Telenti Amalio, Swiss HIV Cohort Study in Pharmacogenetics and genomics (2005). PubMed

Abstract

Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450 2B6 (CYP2B6). Allele 516 G>T (Gln172His) is associated with diminished activity of this isoenzyme, and may lead to differences in drug exposure.

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