Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans by Neumeister Alexander, Charney Dennis S, Belfer Inna, Geraci Marilla, Holmes Courtney, Sharabi Yehonatan, Alim Tanya, Bonne Omer, Luckenbaugh David A, Manji Husseini, Goldman David, Goldstein David S in Pharmacogenetics and genomics (2005). PubMed

Abstract

alpha2-Adrenoreceptors restrain sympathetic nervous outflows and inhibit release of noradrenaline from sympathetic nerves. In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk.

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