MGMT gene silencing and benefit from temozolomide in glioblastoma by Hegi Monika E, Diserens Annie-Claire, Gorlia Thierry, Hamou Marie-France, de Tribolet Nicolas, Weller Michael, Kros Johan M, Hainfellner Johannes A, Mason Warren, Mariani Luigi, Bromberg Jacoline E C, Hau Peter, Mirimanoff René O, Cairncross J Gregory, Janzer Robert C, Stupp Roger in The New England journal of medicine (2005). PubMed

Abstract

Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.

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