Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery by Nussmeier Nancy A, Whelton Andrew A, Brown Mark T, Langford Richard M, Hoeft Andreas, Parlow Joel L, Boyce Steven W, Verburg Kenneth M in The New England journal of medicine (2005). PubMed

Abstract

Valdecoxib and its intravenous prodrug parecoxib are used to treat postoperative pain but may involve risk after coronary-artery bypass grafting (CABG). We conducted a randomized trial to assess the safety of these drugs after CABG.

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