Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol by Liu Jie, Liu Zhao-Qian, Tan Zhi-Rong, Chen Xiao-Ping, Wang Lian-Sheng, Zhou Gan, Zhou Hong-Hao in Clinical pharmacology and therapeutics (2003). PubMed

Abstract

Our objectives were to determine whether the Gly389 polymorphism of the beta(1)-adrenergic receptor exhibits reduced responsiveness in vivo and to test the hypothesis that the Gly389Arg polymorphism affects the blood pressure and heart rate response to metoprolol.

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