Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein by Kurata Yasuo, Ieiri Ichiro, Kimura Miyuki, Morita Toshihiro, Irie Shin, Urae Akinori, Ohdo Shigehiro, Ohtani Hisakazu, Sawada Yasufumi, Higuchi Shun, Otsubo Kenji in Clinical pharmacology and therapeutics (2002). PubMed

Abstract

Our objective was to quantitate the contribution of the genetic polymorphism of the human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P-glycoprotein.

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