IWPC - International Warfarin Pharmacogenetics Consortium

Host Institution PharmGKB
Email iwpc@pharmgkb.org
Drug(s) Warfarin

Abstract

A number of pharmacogenomics research centers have collected data sets relating warfarin dosing to a variety of clinical and genetic parameters including genotypes of CYP2C9 and VKORC1. There is an interest among these groups in sharing their data, in order to possibly arrive at a consensus model for dosing that is consistent with all data sets. For further information regarding the warfarin consortium, please send email to feedback@pharmgkb.org.

Memorandum of Understanding.

IWPC Team

Data Distributors

  • Academic Sinica, Taiwan, ROC:
    • Ming-Ta M. Lee
    • Yuan-Tsong Chen
  • Chang Gung Memorial Hospital, Chang Gung University, Taiwan, ROC:
    • Ming-Shien Wen
  • China Medical University, Graduate Institute of Chinese Medical School, Taichung, Taiwan, ROC:
    • Ming-Ta M. Lee
  • Hadassah Medical Organization, Israel:
    • Yoseph Caraco
    • Idit Achache
    • Simha Blotnick
    • Mordechai Muszkat
  • Inje University, Korea:
    • Jae-Gook Shin
    • Ho-Sook Kim
  • Instituto Nacional de Cancer, Brazil:
    • Guilherme Suarez-Kurtz
    • Jamila Alessandra Perini
  • Instituto Nacional de Cardiologia Laranjeiras, Brazil:
    • Edimilson Silva-Assunção
  • Intermountain Healthcare, USA:
    • Jeffrey L. Anderson
    • Benjamin D. Horne
    • John F. Carlquist
  • Marshfield Clinic, USA:
    • Michael D. Caldwell
    • Richard L. Berg
    • James K. Burmester
  • National University Hospital, Singapore:
    • Boon Cher Goh
    • Soo-Chin Lee
  • Newcastle University, United Kingdom:
    • Farhad Kamali
    • Elizabeth Sconce
    • Ann K. Daly
  • University of Alabama at Birmingham, USA:
    • Nita A. Limdi
  • University of California, San Francisco, USA:
    • Alan H.B. Wu
  • University of Florida, USA:
    • Julie A. Johnson
    • Taimour Y. Langaee
    • Hua Feng
  • University of Illinois, Chicago, USA:
    • Larisa Cavallari
    • Kathryn Momary
  • University of Liverpool, United Kingdom:
    • Munir Pirmohamed
    • Andrea Jorgensen
    • Cheng Hok Toh
    • Paula Williamson
  • University of North Carolina, USA:
    • Howard McLeod
    • James P. Evans
    • Karen E. Weck
  • University of Pennsylvania, USA:
    • Stephen E. Kimmel
    • Colleen Brensinger
  • University of Tokyo and RIKEN, Japan:
    • Yusuke Nakamura
    • Taisei Mushiroda
  • University of Washington, USA:
    • David Veenstra
    • Lisa Meckley
    • Mark J. Rieder
    • Allan E. Rettie
  • Uppsala University, Sweden:
    • Mia Wadelius
    • Niclas Eriksson
    • H??kan Melhus
  • Vanderbilt University, USA:
    • C. Michael Stein
    • Dan M. Roden
    • Ute Schwartz
    • Daniel Kurnik
  • Washington University in St. Louis, USA:
    • Brian F. Gage
    • Elena Deych
    • Petra Lenzini
    • Charles Eby
  • Wellcome Trust Sanger Institute, United Kingdom:
    • Leslie Y. Chen
    • Panos Deloukas

Statistical Analysis

  • University of Alabama, USA:
    • Nita A. Limdi
  • Marshfield Clinic, USA:
    • Michael D. Caldwell
  • North Carolina State University, USA:
    • Alison Motsinger-Reif
  • Stanford University, USA:
    • Teri E. Klein
    • Russ B. Altman
    • Hersh Sagreiya
    • Balaji S. Srinivasan
  • Uppsala University, Uppsala Clinical Research Center, Sweden:
    • Niclas Eriksson
  • University of California, San Francisco, USA:
    • Alan H.B. Wu
  • University of North Carolina, USA:
    • Michael Wagner
  • University of Florida, USA:
    • Julie A. Johnson
  • University of Pennsylvania, USA:
    • Stephen E. Kimmel
  • University of Wisconsin-Madison, USA:
    • David Page
    • Eric Lantz
    • Tim Chang
  • Vanderbilt University, USA:
    • Marylyn Ritchie
  • Washington University in St. Louis, USA:
    • Brian F. Gage
    • Elena Deych

Genotyping QC of IWPC Samples:

  • Academic Sinica, Taiwan, ROC:
    • Ming-Ta M. Lee
    • Liang-Suei Lu

Data Curation:

  • Stanford University, USA:
    • Teri E. Klein
    • Russ B. Altman
    • Balaji S. Srinivasan
  • University of North Carolina:
    • Michael Wagner
  • Washington University in St. Louis, USA:
    • Elena Dench

Funding Acknowledgements:

  • Academic Sinica, Taiwan, ROC:
    • National Research Program for Genomic Medicine, National Science Council, Taiwan (National Clinical Core, NSC95-3112-B-001-010 and National Genotyping Center, NSC95-3112-B -001-011)
  • Hadassah Medical Organization, Israel:
    • Israeli Science Foundation (789/04), United States - Israel Binational Foundation (2003229), Chief Scientist, Ministry of Health (5745)
  • Inje University, Korea:
    • KOSEF / MOST (No. R13-2007-023-00000-0) and Korea Health 21 R&D Project, Ministry of Health and Welfare, Korea (A030001)
  • Instituto Nacional de C??ncer, Brazil:
    • Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq), Funda????o de Amparo ?? Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Financiadora de Estudos e Projetos (FINEP)
  • Marshfield Clinic, USA:
    • Marshfield Clinic Research Foundation
  • Newcastle University, United Kingdom:
    • National Health Service (NHS) Executive (Northern & Yorkshire)
  • Stanford University, USA:
    • NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM61374)
  • University of Alabama, USA:
    • NIH/NINDS (K23NS45598-01)
  • University of Florida, USA:
    • NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM074492) and NIH/NHLBI (HL068834)
  • University of Illinois, Chicago, USA:
    • The American Association of Colleges of Pharmacy and the American Foundation for Pharmaceutical Education
  • University of Liverpool, United Kingdom:
    • United Kingdom Department of Health
  • University of North Carolina, USA:
    • NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM63340) and North Carolina Biotechnology Company Multidisciplinary Research Grant (2006-MRG-1117)
  • University of Pennsylvania, USA:
    • NIH (R01HL066176, P20RR020741 and K24HL070936)
  • University of Washington, USA:
    • NIH/NIGMS (GM68797 and GM32165), NIH/NINDS (NS053646), CDC National Office of Public Health Genomics (NOPHG) Seed Funding, University of Washington Drug Metabolism, Transport and Pharmacogenomics Research (DMTPR) Program
  • Uppsala University, Sweden:
    • Wellcome Trust, Swedish Funding agencies: the Society of Medicine, the Foundation for Strategic Research, the Heart and Lung Foundation, the S??derberg, Thur??us and Selander Foundations and the Clinical Research Support (ALF)
  • Vanderbilt University, USA:
    • NIH/NIGMS Pharmacogenetics Research Network and Database (U01HL65962)
  • Washington University in St. Louis, USA:
    • NIH (R01HL074724 and R01HL71083) and the American Heart Association