CPIC Gene-Drug Pairs


The Clinical Pharmacogenetics Implementation Consortium (CPIC) addresses some of the barriers to implementation of pharmacogenetic tests into clinical practice.

CPIC guidelines are designed to help clinicians understand HOW available genetic test results should be used to optimize drug therapy, rather than WHETHER tests should be ordered. More...

Introductory Publication - CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

Gene Drug Pairs Status Author Contact Others Involved Publication Link Update (2 years)
TPMT - thiopurines published (online Jan 2011) Mary Relling EE Gardner, WJ Sandborn, K Schmiegelow, C-H Pui, SW Yee, CM Stein, M Whirl-Carrillo, WE Evans and TE Klein http://www.ncbi.nlm.nih.gov/pubmed/21270794 published
CYP2C19 - clopidogrel published (online Jun 2011); endorsed by The American Society of Health-System Pharmacists (ASHP) Alan Shuldiner Stuart Scott, Katrin Sangkuhl, EE Gardner, CM Stein, JS Hulot, JA Johnson, DM Roden, TE Klein http://www.ncbi.nlm.nih.gov/pubmed/23698643 published
CYP2C9, VKORC1 - warfarin published (online Sep 2011) Julie Johnson Li Gong, Michelle Whirl-Carrillo, Jeffrey L. Anderson, Stephen E. Kimmel, Ming Ta Michael Lee, Munir Pirmohamed, Stuart A. Scott, C. Michael Stein, Mia Wadelius, Teri E. Klein, Brian Gage, and Russ B. Altman http://www.ncbi.nlm.nih.gov/pubmed/21900891 underway
CYP2D6 - codeine published (online Dec 2011) Kris Crews Todd Skaar, Andrea Gaedigk, Henry Dunnenberger, Teri Klein, DD Shen, JT Callaghan, ED Kharasch, J. Steve Leeder, Kelly E. Caudle, Cyrine-Eliana Haidar, Senthilkumar Sadhasivam, Cynthia Pows http://www.ncbi.nlm.nih.gov/pubmed/22205192 published
HLA-B - abacavir published (online Feb 2012) Deanna Kroetz Teri Klein, MA Martin, BJ Dong, M Pirmohamed, DW Haas http://www.ncbi.nlm.nih.gov/pubmed/22378157 published
SLCO1B1 - simvastatin published (online May 2012) Laura Ramsey Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Li Gong, Teri Klein, Wadelius M, Niemi M, Russ Wilke http://www.ncbi.nlm.nih.gov/pubmed/22617227 underway
HLA-B - allopurinol published (online Oct 2012) Ming-Ta Michael Lee Teri Klein, Caroline Thorn, Werner Pichler, Wichittra Tassaneeyakul, Taisei Mushiroda, John T. Callaghan, Michael Hershfield, Chang-Youh Tsai, Chen-Yang Shen http://www.ncbi.nlm.nih.gov/pubmed?term=23232549
CYP2D6, CYP2C19 - TCAs published (online March 2013) Kevin Hicks Jesse J. Swen, Caroline F. Thorn, Katrin Sangkuhl, Evan Kharasch, Vicki L. Ellingrod, Todd C. Skaar, Daniel J. Müller, Andrea Gaedigk, Julia C. Stingl http://www.ncbi.nlm.nih.gov/pubmed/23486447
HLA-B - carbamazepine published (online May 2013) Susan Leckband John R. Kelsoe, H. Mark Dunnenberger, Alfred L. George, Jr., Eric Tran, Reisel Berger, Daniel J. Müller, Michelle Whirl-Carrillo, Kelly Caudle, Munir Pirmohamed published
DPYD - 5FU / capecitabine published (online Sept 2013) Kelly E. Caudle Caroline F. Thorn, Teri E. Klein, Jesse J. Swen, Howard L. McLeod, Robert B. Diasio, Matthias Schwab http://www.ncbi.nlm.nih.gov/pubmed/?term=23988873
IL28B - pegIntron published (online Oct 2013) Andrew Muir Li Gong, Samuel G. Johnson, Ming Ta Mike Lee, Marc Williams, Teri E. Klein, David Nelson http://www.ncbi.nlm.nih.gov/pubmed/24096968
HLA-B - phenytoin underway Tom Callaghan Kelly Caudle, Teri Klein, Allan Rettie, Michelle Whirl-Carrillo, Lisa Smith, Ming Ta Michael Lee, Scott Mintzer, Ugur Hodoglugil
G6PD - rasburicase, Septra submitted Ellen McDonagh, Tamara Chang Ellen M. McDonagh, Kevin Hicks, Teri Klein, Mary Relling, Lucio Luzzatto, Howard McLeod
CYP2D6 - SSRIs underway Andrea Gaedigk Rebecca L. Graham, Susan G. Leckband, Katrin Sangkuhl, Todd Skaar, J. Kevin Hicks, Dana L. Chiulli, Yuan Ji, Daniel J. Müller, John R. Kelsoe, Sanaz Farhadian, Richard Weinshilboum, David Mrazek, Teri Klein
CFTR - Ivacaftor published (online March 2014) Kathleen M Giacomini Teri Klein, Ellen McDonagh, Samuel G. Johnson, Sook Wah Yee, Kelly Caudle, J.P. Clancy http://www.ncbi.nlm.nih.gov/pubmed/24598717
CYP3A - tacrolimus underway Ken Thummel Kelly A. Birdwell, Teri Klein, Daniel Klein, Julia Barbarino, Michael Stein, Wolfgang Sadee, Danxin Wang, Sander Vinks, Yijing He, Jesse Swen, Brian Decker, Steven Leeder, Iain MacPhee
UGT1A1 - irinotecan