CPIC: Clinical Pharmacogenetics Implementation Consortium

Host Institution PharmGKB
Email cpic@pharmgkb.org
Drug(s) Azathioprine; Mercaptopurine; Thioguanine; Clopidogrel; Warfarin; Codeine; Capecitabine; Abacavir; Carbamazepine; Phenytoin; Allopurinol; Rasburicase; Irinotecan; Simvastatin
Related Links Publications

The Clinical Pharmacogenetics Implementation Consortium (CPIC) was formed in late 2009, as a shared project between PharmGKB and the Pharmacogenomics Research Network. CPIC guidelines are peer-reviewed and published in a leading journal (in partnership with Clinical Pharmacology and Therapeutics) with simultaneous posting to PharmGKB with supplemental information/data and updates. Anyone with clinical interests in pharmacogenetics is eligible for membership. CPIC's goal is to address some of the barriers to implementation of pharmacogenetic tests into clinical practice.

Read an article describing CPIC's guideline development process:
Incorporation of Pharmacogenomics into Routine Clinical Practice: The Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process.

BACKGROUND

One barrier to clinical implementation of pharmacogenetics is the lack of freely available, peer-reviewed, updatable, and detailed gene/drug clinical practice guidelines. CPIC provides guidelines that enable the translation of genetic laboratory test results into actionable prescribing decisions for specific drugs. The guidelines can center on genes (e.g. thiopurine methyltransferase and its implications for thiopurines) or around drugs (e.g. warfarin and CYP2C9 and VKORC1). Priority is given to genotyping tests that are already offered in CLIA-approved clinical settings.

CPIC GUIDELINES

CPIC guidelines are designed to help clinicians understand HOW available genetic test results should be used to optimize drug therapy, rather than WHETHER tests should be ordered. A key assumption underlying the CPIC guidelines is that clinical high-throughput and pre-emptive (pre-prescription) genotyping will become more widespread, and that clinicians will be faced with having patients' genotypes available even if they have not explicitly ordered a test with a specific drug in mind. Each CPIC guideline adheres to a standard format, and includes a standard system for grading levels of evidence linking genotypes to phenotypes, how to assign phenotypes to clinical genotypes, dosing recommendations based on genotype/phenotype, and a standard system for assigning strength to each dosing recommendation.

CPIC MEMBERSHIP

CPIC welcomes other national and international groups to assist with the clinical implementation of pharmacogenetics. If you are interested in joining the consortium, please review the Memorandum of Understanding for Members and the Memorandum of Understanding for Publications, then send an email to feedback@pharmgkb.org.

CPIC Team

Leader
Mary V. Relling, Pharm.D.
St. Jude Children’s Research Hospital, Memphis
Co-Leader
Teri E. Klein, Ph.D.
Stanford University
Coordinator
Kelly Caudle, Pharm.D., Ph.D.
St. Jude Children’s Research Hospital, Memphis

CPIC Steering Committee

  • St. Jude Children’s Research Hospital, Memphis
    • Mary V. Relling, Pharm.D.
  • Stanford University
    • Teri E. Klein, Ph.D.
  • University of Florida
    • Julie A. Johnson, Pharm.D.
  • NIGMS
    • Rochelle M. Long, Ph.D.
  • Vanderbilt University
    • Dan M. Roden, M.D.
  • University of Toronto and CAMH
    • Rachel F. Tyndale, Ph.D. (observer)

Consortium Members (Alphabetical by Institution)

  • Astellas Pharma Global Development
    • Charles Liu
    • Charles van Sant
  • Baylor College of Medicine
    • Michael Metzker
    • Steven Scherer
  • Cedars-Sinai, Medical Center
    • Frank Ong
  • Cedars-Sinai, Medical Genetics Institute
    • Jerome Rotter
  • Center for Genomic Medicine, RINKEN/Institute of Biomedical Sciences, Academic Sinica, Taiwan
    • Ming-Ta M. Lee
  • Central South University, China
    • He Yijing
  • Children's Cancer Hospital-Egypt 57357
    • Wafaa M. Rashed
  • Children's Mercy Hospital
    • Andrea Gaedigk
    • J. Steven Leeder
  • Cincinnati Children's Hospital Medical Center
    • Senthilkumar Sadhasivam
    • Alexander A. Vinks
    • Cindy Prows
  • Cleveland Clinic
    • Kathryn A. Teng
    • Thomas Daly
  • CompanionDx
    • Janan Arslan
    • Prem Gurnani
    • Mehdi Dehghani
  • Dartmouth College
    • Lionel Lewis
  • Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart
    • Matthias Schwab
  • Democritus University of Thrace Medical School
    • Vangelis G Manolopoulos
  • Fullerton Genetics Center
    • Lynn G. Dressler
  • Geisinger Health System
    • Marc S. Williams
  • Genelex Corporation
    • Tyler Mamiya
  • Icahn School of Medicine at Mount Sinai
    • Aniwaa Obeng
  • Indiana University
    • Todd Skaar
    • Victoria Pratt
    • David Thacker
  • Indiana University and VA
    • Tom Callaghan
  • Instituto Nacional de Câncer
    • Guilherme Suarez-Kurtz
  • Kaiser Permanente Colorado
    • Samuel G. Johnson
  • Kroger Pharmacy
    • Jason Mayes
  • Labanese American University, Lebanon
    • Yolande Saab
  • Leiden University Medical Center
    • Henk-Jan Guchelaar
    • Jesse J. Swen
  • "Luigi Sacco" University Hospital, Italy
    • Renato Colognato
  • Mayo Clinic College of Medicine
    • Matthew Goetz
    • Robert Freimuth
    • Jyoti Pathak
    • Christopher G. Chute
    • Michelle A. Elliott
    • John Logan Black
  • Medco Health Solutions, Inc.
    • Felix Frueh
    • Lynn Wachtel
  • Medical College of Wisconsin
    • Uli Broeckel
  • Millennium Laboratories
    • Andria Del Tredici
  • Moffitt Cancer Center
    • Howard L. McLeod
    • Gillian C. Bell
  • Mount Sinai Medical School
    • Stuart Scott
  • Newcastle University
    • Ann Daly
  • NIH Clinical Center/Laboratory for Informatics Development
    • Vojtech Huser
  • Odense University Hospital, Universtity of Southern Denmark
    • Per Damkier
  • Ohio Northern University
    • David Kisor
  • Ohio State University
    • Wolfgang Sadee
    • Audrey Papp
    • Mitch Phelps
    • Jasmine Talameh
  • Omicia, Inc.
  • Trish Brown
  • Pennsylvania State University
    • Marylyn Ritchie
  • Program in Personalized Medicine and Targeted Therapeutics
    • Amalia M. Issa
  • Pharmacogenomics Centre
    • Michael Phillips
  • SRI International
    • Andrew W. Bergen
  • St. Jude Children's Research Hospital
    • Mary V. Relling
    • James M. Hoffman
    • Kristine Crews
    • Fran Green
    • Cyrine-Eliana Haidar
    • Kelly Caudle
    • Tamara Chang
    • Mark Dunnenberger
    • Kevin Hicks
    • Fran Greeson
  • Stanford University
    • Russ B. Altman
    • Michelle Whirl-Carrillo
    • Teri E. Klein
    • Julia Barbarino
    • Li Gong
    • Katrin Sangkuhl
    • Ellen McDonagh
  • The Johns Hopkins University School of Medicine
    • Eric E. Gardner
  • The University of Texas Health Science Center at Houston
    • Kevin Rosenblatt
  • Translational Software
    • Houda Hachad
  • University of Alabama
    • Nita Limdi
  • University at Buffalo, The State University of New York
    • Javier G. Blanco
  • University of California, San Diego
    • Grace M. Kuo
  • University of California, San Francisco
    • Sook Wah Yee
    • Jaekyu Shin
    • Ogechi Ikediobi
    • Wendy Lorizio
    • Michael Martin
    • Deanna Kroetz
    • Grace Kuo
  • University of Chicago
    • M. Eileen Dolan
    • Peter H. O'Donnell
    • Nancy Cox
    • Tamiko Charley
  • University of Extremadura, Spain
    • José A.G. Agúndez
  • University of Florida
    • Julie A. Johnson
    • Kristin Weitzel
  • University of Houston
    • Amalia M. Issa
  • University of Illinois at Chicago College of Pharmacy
    • Jeffrey R. Bishop
  • University of Liverpool
    • Munir Pirmohamed
  • University of Ljubijana, Slovenia
    • Vita Dolzan
  • University of Malta
    • Francesca Wirth
    • Lilian Azzopardi
  • University of Manchester
    • William Newman
  • University of Maryland
    • Alan Shuldiner
    • Joshua Lewis
    • Casey Lynnette Overby
  • University of Michigan College of Pharmacy
    • Dan Hertz
  • University of Pennsylvania
    • Caryn Lerman
    • Falk Lohoff
  • University of Pittsburgh
    • Philip Empey
    • James Coons
  • University of Toronto
    • James L. Kennedy
    • Daniel J. Müller
  • University of Toronto and CAMH
    • Rachel F. Tyndale
  • University Ulm
    • Julia C. Stingl
  • Uppsala University
    • Mia Wadelius
  • Vanderbilt University
    • Christie Ingram
    • Dan M. Roden
    • Charles M. Stein
    • Russell A. Wilke
    • Otito Frances Iwuchukwu
    • Mike Stein
    • Jason Karnes
  • Veterans Affairs San Diego Healthcare System
    • Susan G. Leckband
    • Christine Ngyuen
    • Margaret Mendes
  • Washington University in St. Louis
    • Brian F. Gage

Observers

  • NIH/National Center for Biotechnology Information
    • Adriana Malheiro
  • NIH/National Cancer Institute
    • Kelly Filipski
    • Ravie Kem
    • Minkyung Song
  • NIH/National Human Genome Research Institute
    • Lucia Hindorff
    • Teri Manolio
    • Simona Volpi
  • NIH/National Institute of General Medical Sciences
    • Rochelle M. Long
  • NIH/National Heart, Lung, and Blood Institute
    • Dina N. Paltoo
  • NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development
    • Zhaoxia Ren
  • NIH/National Institute on Drug Abuse
    • Kristopher Bough
  • U.S. Food and Drug Administration
    • Issam Zineh
    • Mark Avigan

Working Group Site