Gene:
TNF
tumor necrosis factor

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs1799724 *1012C>T, -1037C>T, 2828023C>T, 2836120C>T, 2873283C>T, 2885366C>T, 2922188C>T, 3052098C>T, 31482482C>T, 31542482C>T, 4133C>T, 7607C>T, TNF:-850C-T, TNF:-857 C/T
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs1799964 *838T>C, -1211T>C, -1834A>G, -1836A>G, 2827849C>C, 2835946C>C, 2873109T>C, 2885192T>C, 2922014C>C, 3051924T>C, 31482308T>C, 31542308T>C, 3959T>C, 7433T>C, TNF: -1031 T/C, TNF: ¿1031 T/C, TNF:¿1031 T/C
T > C
5' Flanking
No VIP available No Clinical Annotations available VA
rs1800610 186+123G>A, 2829368G>A, 2837465G>A, 2858545G>A, 2874628G>A, 2886711G>A, 2923533G>A, 3053443G>A, 31483827G>A, 31543827G>A, 5478G>A, 8952G>A
G > A
Intronic
No VIP available CA VA
rs1800629 -308, -308G>A, -488G>A, 2828572G>A, 2836669G>A, 2873832G>A, 2885915G>A, 2922737G>A, 3052647A>A, 31483031G>A, 31543031G>A, 4682G>A, 8156G>A, TNF alpha -308G/A, TNF2, TNF:, TNF:-308 G/A, TNF:-308G/A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs1800630 *1006C>A, -1043C>A, 2828017C>A, 2836114C>A, 2873277C>A, 2885360C>A, 2922182A>A, 3052092C>A, 31482476C>A, 31542476C>A, 4127C>A, 7601C>A
C > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs1800750 -556G>A, 2828504G>A, 2836601A>A, 2873764G>A, 2885847G>A, 2922669G>A, 3052579G>A, 31482963G>A, 31542963G>A, 4614G>A, 8088G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs2736195 -828A>G, 2828232A>G, 2836329A>G, 2873492A>G, 2885575A>G, 2922397A>G, 3052307A>G, 31482691A>G, 31542691A>G, 4342A>G, 7816A>G
A > G
5' Flanking
No VIP available No Clinical Annotations available VA
rs3093548 -699C>T, 2828361C>T, 2836458C>T, 2873621C>T, 2885704C>T, 2922526C>T, 3052436C>T, 31482820C>T, 31542820C>T, 4471C>T, 7945C>T
C > T
5' Flanking
No VIP available CA VA
rs3093726 2832330C>C, 2840429T>C, 2861507T>C, 2877590T>C, 2889673T>C, 2926495T>C, 3056405T>C, 31486789T>C, 31546789T>C, 8440T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs361525 -418G>A, 2828642A>A, 2836739A>A, 2873902G>A, 2885985G>A, 2922807G>A, 3052717G>A, 31483101G>A, 31543101G>A, 4752G>A, 8226G>A, TNF:-238 G/A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs4248158 *1063C>T, -986C>T, 2828074C>T, 2836171C>T, 2873334C>T, 2885417C>T, 2922239C>T, 3052149C>T, 31482533C>T, 31542533C>T, 4184C>T, 7658C>T
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs4248159 *1110C>A, -939C>A, 2828121C>A, 2836218C>A, 2873381C>A, 2885464C>A, 2922286C>A, 3052196C>A, 31482580C>A, 31542580C>A, 4231C>A, 7705C>A
C > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs4248160 -826G>A, 2828234G>A, 2836331G>A, 2873494G>A, 2885577G>A, 2922399G>A, 3052309G>A, 31482693G>A, 31542693G>A, 4344G>A, 7818G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs4248163 -691C>G, 2828369C>G, 2836466C>G, 2873629C>G, 2885712C>G, 2922534C>G, 3052444C>G, 31482828C>G, 31542828C>G, 4479C>G, 7953C>G
C > G
5' Flanking
No VIP available No Clinical Annotations available VA
rs4647198 *865C>T, -1184C>T, -1861G>A, -1863G>A, 2827876C>T, 2835973C>T, 2873136C>T, 2885219C>T, 2922041C>T, 3051951C>T, 31482335C>T, 31542335C>T, 3986C>T, 7460C>T
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs4987086 *1087G>A, -962G>A, 2828098G>A, 2836195G>A, 2873358G>A, 2885441G>A, 2922263G>A, 3052173G>A, 31482557G>A, 31542557G>A, 4208G>A, 7682G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs55634887 -636G>A, 2828424G>A, 2836521G>A, 2873684G>A, 2885767G>A, 2922589G>A, 3052499G>A, 31482883G>A, 31542883G>A, 4534G>A, 8008G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs55994001 -637C>T, 2828423C>T, 2836520C>T, 2873683C>T, 2885766C>T, 2922588C>T, 3052498C>T, 31482882C>T, 31542882C>T, 4533C>T, 8007C>T
C > T
5' Flanking
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  TNF superfamily, member 2
Alternate Symbols:  DIF; TNF-alpha; TNFSF2
PharmGKB Accession Id: PA435

Details

Cytogenetic Location: chr6 : p21.33 - p21.33
GP mRNA Boundary: chr6 : 31543350 - 31546112
GP Gene Boundary: chr6 : 31533350 - 31549112
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
    Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.

External Pathways

Links to non-PharmGKB pathways.

  1. amb2 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  3. cadmium induces dna synthesis and proliferation in macrophages - (BioCarta via Pathway Interaction Database)
  4. Calcineurin-regulated NFAT-dependent transcription in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  5. Canonical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
  6. Caspase cascade in apoptosis - (Pathway Interaction Database NCI-Nature Curated)
  7. Cellular roles of Anthrax toxin - (Pathway Interaction Database NCI-Nature Curated)
  8. ceramide signaling pathway - (BioCarta via Pathway Interaction Database)
  9. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  10. Downstream signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  11. hiv-1 nef: negative effector of fas and tnf - (BioCarta via Pathway Interaction Database)
  12. HIV-1 Nef: Negative effector of Fas and TNF-alpha - (Pathway Interaction Database NCI-Nature Curated)
  13. il-10 anti-inflammatory signaling pathway - (BioCarta via Pathway Interaction Database)
  14. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  15. IL27-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  16. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  17. nf-kb signaling pathway - (BioCarta via Pathway Interaction Database)
  18. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  19. nfkb activation by nontypeable hemophilus influenzae - (BioCarta via Pathway Interaction Database)
  20. RXR and RAR heterodimerization with other nuclear receptor - (Pathway Interaction Database NCI-Nature Curated)
  21. signal transduction through il1r - (BioCarta via Pathway Interaction Database)
  22. Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)
  23. sodd/tnfr1 signaling pathway - (BioCarta via Pathway Interaction Database)
  24. stress induction of hsp regulation - (BioCarta via Pathway Interaction Database)
  25. TNF receptor signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  26. TNF signaling - (Reactome via Pathway Interaction Database)
  27. tnf/stress related signaling - (BioCarta via Pathway Interaction Database)
  28. tnfr1 signaling pathway - (BioCarta via Pathway Interaction Database)
  29. visceral fat deposits and the metabolic syndrome - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Curated Information ?

Publications related to TNF: 57

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics in rheumatoid arthritis: how close are we to the clinic?. Pharmacogenomics. 2014. Ponchel Frederique, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Single nucleotide polymorphic macrophage cytokine regulation by Mycobacterium tuberculosis and drug treatment. Pharmacogenomics. 2014. Singh Amit K, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of TNF-alpha polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis. Pharmacogenomics. 2013. Tong Qiang, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association between tumor necrosis factor-alpha (TNF-alpha) promoter -308 G/A and response to TNF-alpha blockers in rheumatoid arthritis: a meta-analysis. Modern rheumatology / the Japan Rheumatism Association. 2013. Zeng Zhen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn's disease and ulcerative colitis. European journal of clinical pharmacology. 2013. Lacruz-Guzmán Diana, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine. Pharmacogenomics. 2013. Umićević Mirkov Maša, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases. The pharmacogenomics journal. 2013. Prieto-Pérez R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Innate immune gene polymorphisms in tuberculosis. Infection and immunity. 2012. Azad Abul K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis. Joint, bone, spine : revue du rhumatisme. 2012. Daïen Claire Immediato, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
TNF-alpha genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis. Liver international : official journal of the International Association for the Study of the Liver. 2012. Kim Sang-Heon, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic and genomic predictors of anti-TNF response. Pharmacogenomics. 2011. Prajapati Rita, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients. Tissue antigens. 2011. Chew C S N, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. British journal of pharmacology. 2010. Collino Massimo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. The pharmacogenomics journal. 2010. Ho-Pun-Cheung A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Key factors in the discovery and development of new antiepileptic drugs. Nature reviews. Drug discovery. 2010. Bialer Meir, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The TNF superfamily in 2009: new pathways, new indications, and new drugs. Drug discovery today. 2009. Tansey Malú G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. Arthritis and rheumatism. 2009. Varani Katia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009. Reyes-Gibby Cielito C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A pharmacodynamic Markov mixed-effects model for determining the effect of exposure to certolizumab pegol on the ACR20 score in patients with rheumatoid arthritis. Clinical pharmacology and therapeutics. 2009. Lacroix B D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease. 2009. Hu Yun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford, England). 2009. Lee Yvonne C, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. The pharmacogenomics journal. 2009. O'Rielly D D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. Pharmacogenomics. 2009. Alfirevic Ana, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. Genomics. 2009. Yoshida Tetsuro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Chronic obstructive pulmonary disease: towards pharmacogenetics. Genome medicine. 2009. Wood Alice M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. Blood. 2008. Atkinson Sarah H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Human molecular genetics. 2008. Maxwell James R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. Tissue antigens. 2008. Dhiman N, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of four DNA polymorphisms with acute rejection after kidney transplantation. Transplant international : official journal of the European Society for Organ Transplantation. 2008. Grinyó Josep, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Clozapine-induced agranulocytosis and its genetic determinants. Pharmacogenomics. 2008. Opgen-Rhein Carolin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tumor necrosis factor-alpha antagonism improves endothelial dysfunction in patients with Crohn's disease. Clinical pharmacology and therapeutics. 2008. Schinzari F, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Effect of the TNFalpha-308 G/A polymorphism on the changes produced by atorvastatin in bone mineral density in patients with acute coronary syndrome. Annals of nutrition & metabolism. 2008. Pérez-Castrillón José Luis, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. American journal of human genetics. 2007. Ayodo George, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007. Ito Noriyuki, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis. Pharmacogenomics. 2007. Coenen Marieke J H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. American journal of human genetics. 2007. Yang Yan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease. Drug discovery today. 2007. Kooloos Wouter M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature genetics. 2007. Bertram Lars, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. Rheumatology (Oxford, England). 2007. Seitz M, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatology international. 2006. Lee Young Ho, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature genetics. 2006. de Bakker Paul I W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy. Clinical pharmacology and therapeutics. 2006. Sugimoto Mitsushige, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006. Kiaei Mahmoud, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American journal of respiratory and critical care medicine. 2005. Wenten Madé, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The effect of proinflammatory cytokine gene and angiotensin-converting enzyme polymorphisms on erythropoietin requirements in patients on continuous ambulatory peritoneal dialysis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2006. Sharples Edward J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scandinavian journal of rheumatology. 2006. Cuchacovich M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Overview of the pharmacogenetics of HIV therapy. The pharmacogenomics journal. 2006. Rodríguez-Nóvoa S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis and rheumatism. 2004. Criswell Lindsey A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese. Journal of clinical periodontology. 2003. Soga Yoshihiko, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma. Blood. 2002. Neben Kai, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. Scandinavian journal of gastroenterology. 2002. Louis E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet. 2002. Mallal S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clinical and experimental immunology. 2001. Roth-Isigkeit A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2001. Awad M R, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients. Neurology. 2001. Pirmohamed M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tumor necrosis factor gene polymorphism and septic shock in surgical infection. Critical care medicine. 2000. Tang G J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Modulation of Mycoplasma arthritidis-derived superantigen-induced cytokine gene expression by dexamethasone and interleukin-4. Infection and immunity. 1994. Mehindate K, et al. PubMed