Gene:
IRS2
insulin receptor substrate 2

PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.

PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.

PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA375

Details

Cytogenetic Location: chr13 : q34 - q34
GP mRNA Boundary†: chr13 : 110406184 - 110438914
GP Gene Boundary†: chr13 : 110403184 - 110448914
Strand: minus
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Representation of anti-diabetic drugs repaglinide, nateglinide and sulfonylurea effects on insulin secretion in pancreatic cells.

External Pathways

Links to non-PharmGKB pathways.

  1. EPO signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  2. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  3. IL4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  4. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)

Publications related to IRS2: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood. 2007. Tissing Wim J E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 2007. Wood Laura D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. The Journal of biological chemistry. 2006. Park Sunmin, et al. PubMed

LinkOuts

Entrez Gene:
8660
OMIM:
125853
600797
UCSC Genome Browser:
NM_003749
RefSeq RNA:
NM_003749
RefSeq Protein:
NP_003740
RefSeq DNA:
AC_000056
AC_000145
NC_000013
NG_008154
NT_009952
NW_001838084
NW_925517
UniProtKB:
IRS2_HUMAN (Q9Y4H2)
Ensembl:
ENSG00000185950
GenAtlas:
IRS2
GeneCard:
IRS2
MutDB:
IRS2
ALFRED:
LO095303U
HuGE:
IRS2
Comparative Toxicogenomics Database:
8660
ModBase:
Q9Y4H2
HGNC:
6126

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