PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
|Alternate Symbols: ||None|
|PharmGKB Accession Id:||PA375|
|Cytogenetic Location:||chr13 : q34 - q34|
|GP mRNA Boundary†:||chr13 : 110406184 - 110438914|
|GP Gene Boundary†:||chr13 : 110403184 - 110448914|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
Representation of anti-diabetic drugs repaglinide, nateglinide and sulfonylurea effects on insulin secretion in pancreatic cells.
Links to non-PharmGKB pathways.
- EPO signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
- IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
- IL4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
- Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
Publications related to IRS2: 3
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood. 2007. Tissing Wim J E, et al.|
||The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 2007. Wood Laura D, et al.|
||Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. The Journal of biological chemistry. 2006. Park Sunmin, et al.|