Gene:
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  14-3-3 eta
Alternate Symbols:  None
PharmGKB Accession Id: PA37442

Details

Cytogenetic Location: chr22 : q12.3 - q12.3
GP mRNA Boundary: chr22 : 32340479 - 32353590
GP Gene Boundary: chr22 : 32330479 - 32356590
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. akt signaling pathway - (BioCarta via Pathway Interaction Database)
  2. cdc25 and chk1 regulatory pathway in response to dna damage - (BioCarta via Pathway Interaction Database)
  3. cell cycle: g2/m checkpoint - (BioCarta via Pathway Interaction Database)
  4. control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) - (BioCarta via Pathway Interaction Database)
  5. multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation - (BioCarta via Pathway Interaction Database)
  6. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  7. rb tumor suppressor/checkpoint signaling in response to dna damage - (BioCarta via Pathway Interaction Database)
  8. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
  9. regulation of cell cycle progression by plk3 - (BioCarta via Pathway Interaction Database)
  10. Regulation of glucocorticoid receptor - (Pathway Interaction Database NCI-Nature Curated)
  11. regulation of pgc-1a - (BioCarta via Pathway Interaction Database)
  12. role of nicotinic acetylcholine receptors in the regulation of apoptosis - (BioCarta via Pathway Interaction Database)
  13. signal dependent regulation of myogenesis by corepressor mitr - (BioCarta via Pathway Interaction Database)

LinkOuts

Entrez Gene:
7533
OMIM:
113508
UCSC Genome Browser:
NM_003405
RefSeq RNA:
NM_003405
RefSeq Protein:
NP_003396
RefSeq DNA:
AC_000065
AC_000154
NC_000022
NT_011520
NW_001838745
NW_927628
UniProtKB:
1433F_HUMAN (Q04917)
Q9H4N8_HUMAN (Q9H4N8)
Ensembl:
ENSG00000128245
GenAtlas:
YWHAH
GeneCard:
YWHAH
MutDB:
YWHAH
ALFRED:
LO185423X
HuGE:
YWHAH
Comparative Toxicogenomics Database:
7533
ModBase:
Q04917
HumanCyc Gene:
HS05165
HGNC:
12853

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