Gene:
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  14-3-3 alpha; 14-3-3 beta
Alternate Symbols:  None
PharmGKB Accession Id: PA37438

Details

Cytogenetic Location: chr20 : q13.12 - q13.12
GP mRNA Boundary: chr20 : 43514344 - 43537161
GP Gene Boundary: chr20 : 43504344 - 43540161
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

Entrez Gene:
7529
OMIM:
601289
UCSC Genome Browser:
NM_003404
RefSeq RNA:
NM_003404
NM_139323
RefSeq Protein:
NP_003395
NP_647539
RefSeq DNA:
AC_000063
AC_000152
NC_000020
NT_011362
NW_001838666
NW_927339
UniProtKB:
1433B_HUMAN (P31946)
Ensembl:
ENSG00000166913
GenAtlas:
YWHAA
YWHAB
GeneCard:
YWHAA
YWHAB
MutDB:
YWHAA
YWHAB
ALFRED:
LO192162V
HuGE:
YWHAA
YWHAB
Comparative Toxicogenomics Database:
7529
ModBase:
P31946
HumanCyc Gene:
HS09479
HGNC:
12849

Common Searches