Gene:
VLDLR
very low density lipoprotein receptor

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  CARMQ1; CHRMQ1; VLDLRCH
PharmGKB Accession Id: PA37317

Details

Cytogenetic Location: chr9 : p24.2 - p24.2
GP mRNA Boundary: chr9 : 2621793 - 2654485
GP Gene Boundary: chr9 : 2611793 - 2657485
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Lissencephaly gene (LIS1) in neuronal migration and development - (Pathway Interaction Database NCI-Nature Curated)
  2. Reelin signaling pathway - (Pathway Interaction Database NCI-Nature Curated)

Publications related to VLDLR: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. American journal of human genetics. 2012. Asselbergs Folkert W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Estimating coverage and power for genetic association studies using near-complete variation data. Nature genetics. 2008. Bhangale Tushar R, et al. PubMed

LinkOuts

Entrez Gene:
7436
OMIM:
192977
224050
UCSC Genome Browser:
NM_003383
RefSeq RNA:
NM_001018056
NM_003383
RefSeq Protein:
NP_001018066
NP_003374
RefSeq DNA:
AC_000052
AC_000141
NC_000009
NG_012741
NT_008413
NW_001839149
NW_924062
UniProtKB:
VLDLR_HUMAN (P98155)
Q5VVF5_HUMAN (Q5VVF5)
Ensembl:
ENSG00000147852
GenAtlas:
VLDLR
GeneCard:
VLDLR
MutDB:
VLDLR
ALFRED:
LO042588B
HuGE:
VLDLR
Comparative Toxicogenomics Database:
7436
ModBase:
P98155
HumanCyc Gene:
HS07471
HGNC:
12698

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