Gene:
VCL
vinculin

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  metavinculin
Alternate Symbols:  None
PharmGKB Accession Id: PA37288

Details

Cytogenetic Location: chr10 : q22.2 - q22.2
GP mRNA Boundary: chr10 : 75757872 - 75879918
GP Gene Boundary: chr10 : 75747872 - 75882918
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Hypertension

Publications related to VCL: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

Entrez Gene:
7414
OMIM:
193065
611407
613255
UCSC Genome Browser:
NM_003373
RefSeq RNA:
NM_003373
NM_014000
RefSeq Protein:
NP_003364
NP_054706
RefSeq DNA:
AC_000053
AC_000142
NC_000010
NG_008868
NT_030059
NW_001837987
NW_924796
UniProtKB:
B3KXA2_HUMAN (B3KXA2)
VINC_HUMAN (P18206)
Ensembl:
ENSG00000035403
GenAtlas:
VCL
GeneCard:
VCL
MutDB:
VCL
ALFRED:
LO028939F
HuGE:
VCL
Comparative Toxicogenomics Database:
7414
ModBase:
P18206
HumanCyc Gene:
HS00506
HGNC:
12665

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