Gene:
USP5
ubiquitin specific peptidase 5 (isopeptidase T)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs2301339 10250G>A, 47044G>A, 6894624G>A, 6954624G>A, 700-126G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs5442 10490G>A, 47284G>A, 6894864G>A, 6954864G>A, 814G>A, GNB3:814G>A, GNB3:Gly272Ser, Gly272Ser
G > A
Missense
Gly272Ser
No VIP available No Clinical Annotations available VA
rs5443 10501C>T, 47295C>T, 6894875C>T, 6954875C>T, 825C>T, GNB3:825C>T, GNB3:Ser275Ser, Ser275=
C > T
Synonymous
Ser275Ser
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  IsoT
PharmGKB Accession Id: PA37253

Details

Cytogenetic Location: chr12 : p13.31 - p13.31
GP mRNA Boundary: chr12 : 6961285 - 6975796
GP Gene Boundary: chr12 : 6951285 - 6978796
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
hydrochlorothiazide
Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Beta Blocking Agents
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
diuretics

Curated Information ?

Publications related to USP5: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
beta-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein beta-3 subunit variant. Pharmacogenomics. 2010. Dörr Marcus, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Diuretic-gene interaction and the risk of myocardial infarction and stroke. The pharmacogenomics journal. 2007. Schelleman H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. The pharmacogenomics journal. 2006. Schelleman H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diuretic. Hypertension. 2001. Turner S T, et al. PubMed

LinkOuts

Entrez Gene:
8078
OMIM:
601447
UCSC Genome Browser:
NM_003481
RefSeq RNA:
NM_001098536
NM_003481
RefSeq Protein:
NP_001092006
NP_003472
RefSeq DNA:
AC_000055
AC_000144
NC_000012
NT_009759
NW_001838050
NW_925295
UniProtKB:
UBP5_HUMAN (P45974)
Ensembl:
ENSG00000111667
GenAtlas:
USP5
GeneCard:
USP5
MutDB:
USP5
ALFRED:
LO011047N
HuGE:
USP5
Comparative Toxicogenomics Database:
8078
ModBase:
P45974
HumanCyc Gene:
HS03440
HGNC:
12628

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