Gene:
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  PGP9.5; Uch-L1
PharmGKB Accession Id: PA37160

Details

Cytogenetic Location: chr4 : p14 - p13
GP mRNA Boundary: chr4 : 41258898 - 41270446
GP Gene Boundary: chr4 : 41248898 - 41273446
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Alpha-synuclein signaling - (Pathway Interaction Database NCI-Nature Curated)

LinkOuts

Entrez Gene:
7345
OMIM:
168600
191342
UCSC Genome Browser:
NM_004181
RefSeq RNA:
NM_004181
RefSeq Protein:
NP_004172
RefSeq DNA:
AC_000047
AC_000136
NC_000004
NG_012931
NT_006238
NW_001838903
NW_922073
UniProtKB:
UCHL1_HUMAN (P09936)
Ensembl:
ENSG00000154277
GenAtlas:
UCHL1
GeneCard:
UCHL1
MutDB:
UCHL1
ALFRED:
LO005457V
HuGE:
UCHL1
Comparative Toxicogenomics Database:
7345
ModBase:
P09936
HumanCyc Gene:
HS07970
HGNC:
12513

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