Gene:
TRPC6
transient receptor potential cation channel, subfamily C, member 6

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  TRP6
PharmGKB Accession Id: PA37011

Details

Cytogenetic Location: chr11 : q22.1 - q22.1
GP mRNA Boundary: chr11 : 101322295 - 101454659
GP Gene Boundary: chr11 : 101319295 - 101464659
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Endothelins - (Pathway Interaction Database NCI-Nature Curated)
  2. EPO signaling pathway - (Pathway Interaction Database NCI-Nature Curated)

Publications related to TRPC6: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of VX-770 (Ivacaftor) and OAG on Ca(2+) influx and CFTR activity in G551D and F508del-CFTR expressing cells. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2013. Vachel Laura, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science (New York, N.Y.). 2005. Winn Michelle P, et al. PubMed

LinkOuts

Entrez Gene:
7225
OMIM:
603652
603965
UCSC Genome Browser:
NM_004621
RefSeq RNA:
NM_004621
RefSeq Protein:
NP_004612
RefSeq DNA:
AC_000054
AC_000143
NC_000011
NG_011476
NT_033899
NW_001838042
NW_925173
UniProtKB:
TRPC6_HUMAN (Q9Y210)
Ensembl:
ENSG00000137672
GenAtlas:
TRPC6
GeneCard:
TRPC6
MutDB:
TRPC6
ALFRED:
LO003577W
HuGE:
TRPC6
Comparative Toxicogenomics Database:
7225
ModBase:
Q9Y210
HumanCyc Gene:
HS06370
IUPHAR Receptor:
TRPC6 (491)
HGNC:
12338

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