Gene:
TLR3
toll-like receptor 3

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs3775291 111551795C>T, 1234C>T, 187004074C>T, 18766C>T, Leu412Phe, TLR3: L412F, TLR3: P412L
C > T
Missense
Leu412Phe
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  CD283
PharmGKB Accession Id: PA36551

Details

Cytogenetic Location: chr4 : q35.1 - q35.1
GP mRNA Boundary: chr4 : 186990309 - 187006252
GP Gene Boundary: chr4 : 186980309 - 187009252
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
aspirin
Evidence Drug Class
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Measles vaccines

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Asthma

Publications related to TLR3: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease. Allergy, asthma & immunology research. 2011. Palikhe Nami Shrestha, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. The New England journal of medicine. 2008. Yang Zhenglin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008. Kleinman Mark E, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. Vaccine. 2008. Dhiman Neelam, et al. PubMed

LinkOuts

Entrez Gene:
7098
OMIM:
603029
603075
613002
UCSC Genome Browser:
NM_003265
RefSeq RNA:
NM_003265
RefSeq Protein:
NP_003256
RefSeq DNA:
AC_000047
AC_000136
NC_000004
NG_007278
NT_016354
NW_001838921
NW_922217
UniProtKB:
TLR3_HUMAN (O15455)
Ensembl:
ENSG00000164342
GenAtlas:
TLR3
GeneCard:
TLR3
MutDB:
TLR3
ALFRED:
LO014107N
HuGE:
TLR3
Comparative Toxicogenomics Database:
7098
ModBase:
O15455
HumanCyc Gene:
HS09066
HGNC:
11849

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