serine/threonine kinase 11
On ACMG incidental findings list
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Names:||polarization-related protein LKB1|
|Alternate Symbols: ||LKB1; PJS|
|PharmGKB Accession Id:||PA36198|
|Cytogenetic Location:||chr19 : p13.3 - p13.3|
|GP mRNA Boundary†:||chr19 : 1205798 - 1228434|
|GP Gene Boundary†:||chr19 : 1195798 - 1231434|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Links to non-PharmGKB pathways.
Publications related to STK11: 6
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
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||Role of solute carrier transporters in pancreatic cancer: a review. Pharmacogenomics. 2014. Lemstrová Radmila, et al.|
||ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genetics in medicine : official journal of the American College of Medical Genetics. 2013. Green Robert C, et al.|
||CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer. Pharmacogenomics. 2010. Metzger Ralf, et al.|
||The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature reviews. Cancer. 2009. Shackelford David B, et al.|
||Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome. Pharmacogenomics. 2008. Goldenberg Naila, et al.|
||Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene. The Journal of clinical endocrinology and metabolism. 2008. Legro Richard S, et al.|