Gene:
SNCA
synuclein, alpha (non A4 component of amyloid precursor)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  NACP; PD1; alpha-synuclein
PharmGKB Accession Id: PA35986

Details

Cytogenetic Location: chr4 : q22.1 - q22.1
GP mRNA Boundary: chr4 : 90645250 - 90759447
GP Gene Boundary: chr4 : 90642250 - 90769447
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease - (BioCarta via Pathway Interaction Database)
  2. Alpha-synuclein signaling - (Pathway Interaction Database NCI-Nature Curated)

Publications related to SNCA: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PloS one. 2009. Al-Chalabi Ammar, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.). 2006. Cooper Antony A, et al. PubMed

LinkOuts

UniProtKB:
SYUA_HUMAN (P37840)
Ensembl:
ENSG00000145335
GenAtlas:
SNCA
GeneCard:
SNCA
MutDB:
SNCA
ALFRED:
LO004654T
HuGE:
SNCA
Comparative Toxicogenomics Database:
6622
ModBase:
P37840
HumanCyc Gene:
HS07245
HGNC:
11138

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