Gene:
HLA-DPB1
major histocompatibility complex, class II, DP beta 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA *03:01:01 N/A N/A N/A
No VIP available No VIP available VA *04:01:01:01 N/A N/A N/A
No VIP available No VIP available VA *05:01:01 N/A N/A N/A
No VIP available No VIP available VA *13:01 N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs1042136 -195T>A, -195T>G, -271T>A, -271T>G, 280A>C, 280A>T, 32988628A>C, 32988628A>T, 33048628A>C, 33048628A>T, 4281085A>C, 4281085A>T, 4329967A>C, 4329967A>T, 4335435A>C, 4335435A>T, 4385489A>C, 4385489A>T, 4492807C>C, 4492807C>T, 4506174A>C, 4506174A>T, 4529132A>C, 4529132A>T, Ile94Leu, Ile94Phe
A > T
A > C
Missense
Ile94Leu
Ile94Phe
No VIP available No Clinical Annotations available VA
rs1042151 -228T>C, -304T>C, 313A>G, 32988661A>G, 33048661A>G, 4281118A>G, 4330000A>G, 4335468A>G, 4385522A>G, 4492840G>G, 4506207A>G, 4529165A>G, Met105Val
A > G
Missense
Met105Val
No VIP available No Clinical Annotations available VA
rs3097671 -100+845C>G, -24+845C>G, 101-837G>C, 32987612G>C, 33047612G>C, 4280069G>C, 4328951G>C, 4334419G>C, 4384473G>C, 4491791C>C, 4505158G>C, 4528116G>C, 637G>C
G > C
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  HLA-DP1B
Alternate Symbols:  None
PharmGKB Accession Id: PA35064

Details

Cytogenetic Location: chr6 : p21.32 - p21.32
GP mRNA Boundary: chr6 : 33043703 - 33057473
GP Gene Boundary: chr6 : 33033703 - 33060473
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Haplotype Overview

Source of these HLA allele names: http://hla.alleles.org/ (HLA Informatics Group 1995-2012)

References:

  • [Article:21071412] Robinson J, Mistry K, McWilliam H, Lopez R, Parham P, Marsh SGE: The IMGT/HLA database. Nucleic Acids Research. 2011 39 Suppl 1:D1171-6.
  • [Article:10777106] Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE: IMGT/HLA - a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000 55:280-7.
  • [Article:20356336] SGE Marsh, ED Albert, WF Bodmer, RE Bontrop, B Dupont, HA Erlich, M Fernández-Vina, DE Geraghty, R Holdsworth, CK Hurley, M Lau, KW Lee, B Mach, WR Mayr, M Maiers, CR Müller, P Parham, EW Petersdorf, T Sasazuki, JL Strominger, A Svejgaard, PI Terasaki, JM Tiercy, J Trowsdale: Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75:291-455.

Source: PharmGKB

All alleles in the download file are on the positive chromosomal strand. PharmGKB considers the first haplotype listed in each table as the reference haplotype for that set.

No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
aspirin
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
clozapine

Curated Information ?

Publications related to HLA-DPB1: 11

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Exonic variants associated with development of aspirin exacerbated respiratory diseases. PloS one. 2014. Shin Seung-Woo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Annals of the rheumatic diseases. 2013. Yarwood Annie, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex. Annual review of pharmacology and toxicology. 2012. Bharadwaj Mandvi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. International journal of immunogenetics. 2011. Cristallo A F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The HLA allele marker for differentiating ASA hypersensitivity phenotypes. Allergy. 2009. Lee H-Y, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes, obesity & metabolism. 2009. Howson J M M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Evolution and selection of human leukocyte antigen alleles by Plasmodium falciparum infection. Human immunology. 2008. Ghosh Kanjaksha. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2005. Kim S-H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population. The Journal of allergy and clinical immunology. 2004. Choi Jeong Hee, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. Pharmacogenetics. 2001. Dettling M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1997. Dekker J W, et al. PubMed

LinkOuts

HuGE:
HLA-DPB1
Comparative Toxicogenomics Database:
3115
ModBase:
P01916
P04232
P04440
P13763
HumanCyc Gene:
HS09741
HGNC:
4940

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