sodium channel, voltage-gated, type X, alpha subunit
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Symbols: ||Nav1.8; PN3; SNS; hPN3|
|PharmGKB Accession Id:||PA35000|
|Cytogenetic Location:||chr3 : p22.2 - p22.2|
|GP mRNA Boundary†:||chr3 : 38738837 - 38835501|
|GP Gene Boundary†:||chr3 : 38735837 - 38845501|
Publications related to SCN10A: 4
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- DG Dosing Guideline information is available
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||Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature genetics. 2013. Bezzina Connie R, et al.|
||Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2013. Delaney Jessica T, et al.|
||Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 2013. Ritchie Marylyn D, et al.|
||Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circulation research. 2012. Yang Tao, et al.|