PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
Overview
| Alternate Names: | OTTHUMP00000022510; nuclear receptor subfamily 2 group B member 1; retinoic acid receptor RXR-alpha |
|---|---|
| Alternate Symbols: | FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720; NR2B1 |
| PharmGKB Accession Id: | PA34890 |
Details
| Cytogenetic Location: | chr9 : q34.2 - q34.2 |
|---|---|
| GP mRNA Boundary†: | chr9 : 137218316 - 137332431 |
| GP Gene Boundary†: | chr9 : 137208316 - 137335431 |
| Strand: | plus |
| Product Name: | No data available |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.
External Pathways
Links to non-PharmGKB pathways.
- basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression - (BioCarta via Pathway Interaction Database)
- control of gene expression by vitamin d receptor - (BioCarta via Pathway Interaction Database)
- degradation of the rar and rxr by the proteasome - (BioCarta via Pathway Interaction Database)
- map kinase inactivation of smrt corepressor - (BioCarta via Pathway Interaction Database)
- mechanism of gene regulation by peroxisome proliferators via ppara - (BioCarta via Pathway Interaction Database)
- nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells - (BioCarta via Pathway Interaction Database)
- Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
- role of ppar-gamma coactivators in obesity and thermogenesis - (BioCarta via Pathway Interaction Database)
- RXR and RAR heterodimerization with other nuclear receptor - (Pathway Interaction Database NCI-Nature Curated)
- transcription regulation by methyltransferase of carm1 - (BioCarta via Pathway Interaction Database)
- visceral fat deposits and the metabolic syndrome - (BioCarta via Pathway Interaction Database)
Publications related to RXRA: 4
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Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors. PLoS computational biology. 2009. Xie Li, et al. [Article:19436720@PubMed] |
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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of biological chemistry. 2002. Kast Heidi R, et al. [Article:11706036@PubMed] |
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SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes & development. 1998. Blumberg B, et al. [Article:9784494@PubMed] |
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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. The Journal of clinical investigation. 1998. Lehmann J M, et al. [Article:9727070@PubMed] |
Datasets
LinkOuts
- UniProtKB:
- RXRA_HUMAN (P19793)
- Q2NL52_HUMAN (Q2NL52)
- Q6P3U7_HUMAN (Q6P3U7)
- Ensembl:
- ENSG00000186350
- GenAtlas:
- RXRA
- GeneCard:
- GC09P137208 (6256)
- MutDB:
- RXRA
- ALFRED:
- LO028806Y