Gene:
RXRA
retinoid X receptor, alpha

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all RXRA variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs11185647 124635G>A, 137215828G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs1185648 67430210T>C, 86450210T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs1536475 1043+70A>G, 137321156A>G, 229963A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2234753 137293761G>A, 202568G>A, 279+33G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs3132291 *4458G>A, 137332918G>A, 241725G>A
G > A
3' Flanking
No VIP available No Clinical Annotations available VA
rs35443779 1135+106A>G, 137323948A>G, 232755A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs4240711 *846G>A, 137329306G>A, 238113G>A
G > A
3' UTR
No VIP available No Clinical Annotations available VA
rs62576288 -1741G>A, 125544G>A, 137216737G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs6413517 1043+170T>G, 137321256T>G, 230063T>G
T > G
Intronic
No VIP available No Clinical Annotations available VA
rs7861779 137309461C>T, 218268C>T, 780+288C>T
C > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  nuclear receptor subfamily 2 group B member 1
Alternate Symbols:  NR2B1
PharmGKB Accession Id: PA34890

Details

Cytogenetic Location: chr9 : q34.3 - q34.2
GP mRNA Boundary: chr9 : 137218316 - 137332431
GP Gene Boundary: chr9 : 137208316 - 137335431
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression - (BioCarta via Pathway Interaction Database)
  2. control of gene expression by vitamin d receptor - (BioCarta via Pathway Interaction Database)
  3. degradation of the rar and rxr by the proteasome - (BioCarta via Pathway Interaction Database)
  4. map kinase inactivation of smrt corepressor - (BioCarta via Pathway Interaction Database)
  5. mechanism of gene regulation by peroxisome proliferators via ppara - (BioCarta via Pathway Interaction Database)
  6. nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells - (BioCarta via Pathway Interaction Database)
  7. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  8. role of ppar-gamma coactivators in obesity and thermogenesis - (BioCarta via Pathway Interaction Database)
  9. RXR and RAR heterodimerization with other nuclear receptor - (Pathway Interaction Database NCI-Nature Curated)
  10. transcription regulation by methyltransferase of carm1 - (BioCarta via Pathway Interaction Database)
  11. visceral fat deposits and the metabolic syndrome - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
docetaxel

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Nasopharyngeal Neoplasms

Publications related to RXRA: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRalpha and HNF4alpha) on docetaxel disposition in Chinese nasopharyngeal cancer patients. European journal of clinical pharmacology. 2013. Chew Sin-Chi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. The Journal of steroid biochemistry and molecular biology. 2010. Hibler E A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors. PLoS computational biology. 2009. Xie Li, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of biological chemistry. 2002. Kast Heidi R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes & development. 1998. Blumberg B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. The Journal of clinical investigation. 1998. Lehmann J M, et al. PubMed

LinkOuts

Entrez Gene:
6256
OMIM:
180245
UCSC Genome Browser:
NM_002957
RefSeq RNA:
NM_002957
RefSeq Protein:
NP_002948
RefSeq DNA:
AC_000052
AC_000141
NC_000009
NT_019501
NW_001839244
NW_924573
HuGE:
RXRA
Comparative Toxicogenomics Database:
6256
ModBase:
P19793
HumanCyc Gene:
HS01285
HGNC:
10477

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