Gene:
RUNX2
runt-related transcription factor 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  AML3; PEBP2A1; PEBP2aA1
PharmGKB Accession Id: PA34885

Details

Cytogenetic Location: chr6 : p21.1 - p21.1
GP mRNA Boundary: chr6 : 45296054 - 45518819
GP Gene Boundary: chr6 : 45286054 - 45521819
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. FGF signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  2. Regulation of nuclear SMAD2/3 signaling - (Pathway Interaction Database NCI-Nature Curated)
  3. Regulation of retinoblastoma protein - (Pathway Interaction Database NCI-Nature Curated)

Publications related to RUNX2: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RUNX Transcription Factors: Association with Pediatric Asthma and Modulated by Maternal Smoking. American journal of physiology. Lung cellular and molecular physiology. 2011. Haley Kathleen J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. The Journal of biological chemistry. 2003. Bellido Teresita, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling. Molecular endocrinology (Baltimore, Md.). 2003. Krishnan Venkatesh, et al. PubMed

LinkOuts

UniProtKB:
RUNX2_HUMAN (Q13950)
Ensembl:
ENSG00000124813
ENSG00000250096
GenAtlas:
RUNX2
GeneCard:
RUNX2
MutDB:
RUNX2
ALFRED:
LO001970R
HuGE:
RUNX2
Comparative Toxicogenomics Database:
860
ModBase:
Q13950
HumanCyc Gene:
HS04840
HGNC:
10472

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