Gene:
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  RIP
PharmGKB Accession Id: PA34394

Details

Cytogenetic Location: chr6 : p25.2 - p25.2
GP mRNA Boundary: chr6 : 3077058 - 3115421
GP Gene Boundary: chr6 : 3067058 - 3118421
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Activation of Pro-Caspase 8 - (Reactome via Pathway Interaction Database)
  2. Caspase cascade in apoptosis - (Pathway Interaction Database NCI-Nature Curated)
  3. ceramide signaling pathway - (BioCarta via Pathway Interaction Database)
  4. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  5. FAS signaling pathway (CD95) - (Pathway Interaction Database NCI-Nature Curated)
  6. hiv-1 nef: negative effector of fas and tnf - (BioCarta via Pathway Interaction Database)
  7. HIV-1 Nef: Negative effector of Fas and TNF-alpha - (Pathway Interaction Database NCI-Nature Curated)
  8. induction of apoptosis through dr3 and dr4/5 death receptors - (BioCarta via Pathway Interaction Database)
  9. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  10. nf-kb signaling pathway - (BioCarta via Pathway Interaction Database)
  11. Regulation of p38-alpha and p38-beta - (Pathway Interaction Database NCI-Nature Curated)
  12. sodd/tnfr1 signaling pathway - (BioCarta via Pathway Interaction Database)
  13. TNF receptor signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  14. TNF signaling - (Reactome via Pathway Interaction Database)
  15. tnf/stress related signaling - (BioCarta via Pathway Interaction Database)
  16. tnfr1 signaling pathway - (BioCarta via Pathway Interaction Database)
  17. tnfr2 signaling pathway - (BioCarta via Pathway Interaction Database)
  18. TRAIL signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  19. TRAM Cascade - (Reactome via Pathway Interaction Database)
  20. Viral dsRNA:TLR3:TRIF Complex Activates RIP1 - (Reactome via Pathway Interaction Database)
  21. Viral dsRNA:TLR3:TRIF Complex Activates TBK1 - (Reactome via Pathway Interaction Database)

LinkOuts

Entrez Gene:
8737
OMIM:
603453
UCSC Genome Browser:
NM_003804
RefSeq RNA:
NM_003804
RefSeq Protein:
NP_003795
RefSeq DNA:
AC_000049
AC_000138
NC_000006
NT_007592
NW_001838972
NW_922984
UniProtKB:
RIPK1_HUMAN (Q13546)
Ensembl:
ENSG00000137275
GenAtlas:
RIPK1
GeneCard:
RIPK1
MutDB:
RIPK1
ALFRED:
LO003186S
HuGE:
RIPK1
Comparative Toxicogenomics Database:
8737
ModBase:
Q13546
HumanCyc Gene:
HS06304
HGNC:
10019

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