Gene:
RASA1
RAS p21 protein activator (GTPase activating protein) 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  capillary malformation-arteriovenous malformation
Alternate Symbols:  CM-AVM; GAP; p120GAP; p120RASGAP
PharmGKB Accession Id: PA34232

Details

Cytogenetic Location: chr5 : q13.3 - q14.3
GP mRNA Boundary: chr5 : 86564151 - 86687733
GP Gene Boundary: chr5 : 86554151 - 86690733
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Aurora A signaling - (Pathway Interaction Database NCI-Nature Curated)
  3. Aurora B signaling - (Pathway Interaction Database NCI-Nature Curated)
  4. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  5. Down-stream signal transduction - (Reactome via Pathway Interaction Database)
  6. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  7. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  8. hiv-1 nef: negative effector of fas and tnf - (BioCarta via Pathway Interaction Database)
  9. igf-1 signaling pathway - (BioCarta via Pathway Interaction Database)
  10. IL2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  11. Insulin Pathway - (Pathway Interaction Database NCI-Nature Curated)
  12. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  13. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  14. PDGFR-beta signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  15. regulation of splicing through sam68 - (BioCarta via Pathway Interaction Database)
  16. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  17. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  18. sprouty regulation of tyrosine kinase signals - (BioCarta via Pathway Interaction Database)
  19. Syndecan-2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  20. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
  21. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)

Publications related to RASA1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

UniProtKB:
RASA1_HUMAN (P20936)
Ensembl:
ENSG00000145715
GenAtlas:
RASA1
GeneCard:
RASA1
MutDB:
RASA1
ALFRED:
LO016177W
HuGE:
RASA1
Comparative Toxicogenomics Database:
5921
ModBase:
P20936
HumanCyc Gene:
HS07276
HGNC:
9871

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