Gene:
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  p42
PharmGKB Accession Id: PA33898

Details

Cytogenetic Location: chr14 : q22.1 - q22.1
GP mRNA Boundary: chr14 : 53173896 - 53194716
GP Gene Boundary: chr14 : 53163896 - 53197716
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. APC/C:Cdc20 mediated degradation of Securin - (Reactome via Pathway Interaction Database)
  2. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - (Reactome via Pathway Interaction Database)
  3. Autodegradation of Cdh1 by Cdh1:APC/C - (Reactome via Pathway Interaction Database)
  4. Cdc20:Phospho-APC/C mediated degradation of Cyclin A - (Reactome via Pathway Interaction Database)
  5. CDK-mediated phosphorylation and removal of Cdc6 - (Reactome via Pathway Interaction Database)
  6. CDT1 association with the CDC6:ORC:origin complex - (Reactome via Pathway Interaction Database)
  7. Degradation of beta-catenin by the destruction complex - (Reactome via Pathway Interaction Database)
  8. Orc1 removal from chromatin - (Reactome via Pathway Interaction Database)
  9. Regulation of activated PAK-2p34 by proteasome mediated degradation - (Reactome via Pathway Interaction Database)
  10. Regulation of activated PAK-2p34 by proteasome mediated degradation - (Reactome via Pathway Interaction Database)
  11. Regulation of ornithine decarboxylase (ODC) - (Reactome via Pathway Interaction Database)
  12. SCF(Skp2)-mediated degradation of p27/p21 - (Reactome via Pathway Interaction Database)
  13. SCF-beta-TrCP mediated degradation of Emi1 - (Reactome via Pathway Interaction Database)
  14. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - (Reactome via Pathway Interaction Database)
  15. Ubiquitin-dependent degradation of Cyclin D1 - (Reactome via Pathway Interaction Database)
  16. Vif-mediated degradation of APOBEC3G - (Reactome via Pathway Interaction Database)
  17. Vpu mediated degradation of CD4 - (Reactome via Pathway Interaction Database)

LinkOuts

Entrez Gene:
5706
OMIM:
602708
UCSC Genome Browser:
NM_002806
RefSeq RNA:
NM_002806
RefSeq Protein:
NP_002797
RefSeq DNA:
AC_000057
AC_000146
NC_000014
NT_026437
NW_001838111
NW_925539
UniProtKB:
PRS10_HUMAN (P62333)
Ensembl:
ENSG00000100519
GenAtlas:
PSMC6
GeneCard:
PSMC6
MutDB:
PSMC6
ALFRED:
LO187030T
HuGE:
PSMC6
Comparative Toxicogenomics Database:
5706
ModBase:
P62333
HumanCyc Gene:
HS02101
HGNC:
9553

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