Gene:
PRKCZ
protein kinase C, zeta

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  PKC2
PharmGKB Accession Id: PA33775

Details

Cytogenetic Location: chr1 : p36.33 - p36.33
GP mRNA Boundary: chr1 : 1981909 - 2116834
GP Gene Boundary: chr1 : 1971909 - 2119834
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. Proton Pump Inhibitor Pathway, Pharmacodynamics
    Genes involved in the proton pump activation and trafficking.
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. amb2 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  3. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  4. IL1-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  5. IL2 signaling events mediated by PI3K - (Pathway Interaction Database NCI-Nature Curated)
  6. Insulin Pathway - (Pathway Interaction Database NCI-Nature Curated)
  7. Insulin-mediated glucose transport - (Pathway Interaction Database NCI-Nature Curated)
  8. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  9. p75(NTR)-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  10. phosphoinositides and their downstream targets - (BioCarta via Pathway Interaction Database)
  11. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  12. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  13. TNF receptor signaling pathway - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADRB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
RAF1
No related diseases are available

Publications related to PRKCZ: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nature medicine. 2011. Diouf Barthelemy, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 2007. Wood Laura D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. The Journal of biological chemistry. 2003. MacDonald Patrick E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

UniProtKB:
A8MU64_HUMAN (A8MU64)
KPCZ_HUMAN (Q05513)
Ensembl:
ENSG00000067606
GenAtlas:
PRKCZ
GeneCard:
PRKCZ
MutDB:
PRKCZ
ALFRED:
LO047665C
HuGE:
PRKCZ
Comparative Toxicogenomics Database:
5590
ModBase:
Q05513
HumanCyc Gene:
HS00913
HGNC:
9412

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